Natural history and prognosis of recurrent breast cancer.

نویسندگان

  • S Karabali-Dalamaga
  • R L Souhami
  • N J O'Higgins
  • A Soumilas
  • C G Clark
چکیده

Patterns of recurrent disease were analysed in 603 patients with breast cancer. The time of onset, frequency of recurrence, and survival after recurrence were not influenced by age or menopausal state. While survival after local recurrence was longer than survival after distant metastasis, the time to onset of local and distant disease followed an identical pattern, indicating that local recurrence should be regarded as a manifestation of systemic disease. Postoperative radiotherapy did not affect the time of onset of local recurrence. We suggest that patients with local recurrence should receive both systemic and local treatment and that controlled trials of chemotherapeutic agents in these patients might be valuable in finding the most effective drug combinations to be used as adjuvant treatment after mastectomy.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Upregulation of HOTAIR Transcript Level in Tumor Tissue of Iranian Women with Breast Cancer

Background:Dysregulation of HOX Transcript Antisense Intergenic RNA (HOTAIR) has been linked to the etiopathogenesis of several human cancers. According to epidemiological evidences, the risk of susceptibility to breast cancer varies among different populations. This study was designed to determine the transcriptional level of HOTAIR in tumor cells of breast cancer pat...

متن کامل

ABO blood groups and prognosis of breast cancer: a case-control study in Arak/Iran

Background: To explore a possible rela!onship among blood groups and the prognosis of breast cancer, this case- control study was carried out in Arak city, Arak province, Iran. Materials and Methods: One hundred and thirty four pa!ents with breast cancer were inves!gated. ABO blood groups were obtained from medical records. Mul!variate analyses were performed, including size of tumor, axilla...

متن کامل

Brain metastasis in breast cancer: last barrier to the cure?

The last two decades have seen the development of a variety of novel therapeutic agents that have improved prognoses for women with breast cancer. Certainly for women with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, the introduction of trastuzumab (Herceptin) has altered the natural history of the disease, turning a once aggressive cancer into one with a favorable pr...

متن کامل

Clinical Value of Serum S100A8/A9 and CA15-3 in the Diagnosis of Breast Cancer

Background and Objective: S100A8/A9 is a heterodimer calcium-binding protein which is involved in tumor cell proliferation, adhesion and invasion, and is proposed as a biomarker for better diagnosis and prognosis in many cancers. The aim of this study was to evaluate the simultaneous serum-based level of S100A8/A9 and CA15-3 as well-illustrated cancer biomarkers, as well as the...

متن کامل

A Fuzzy Rule-based Expert System for the Prognosis of the Risk of Development of the Breast Cancer

Soft Computing techniques play an important role for decision in applications with imprecise and uncertain knowledge. The application of soft computing disciplines is rapidly emerging for the diagnosis and prognosis in medical applications. Between various soft computing techniques, fuzzy expert system takes advantage of fuzzy set theory to provide computing with uncertain words. In a fuzzy exp...

متن کامل

Multivariate Frailty Modeling in Joint Analyzing of Recurrent Events with Terminal Event and its Application in Medical Data

Background and Objectives: In many medical situations, people can experience recurrent events with a terminal event. If the terminal event is considered a censor in this type of data, the assumption of independence in the analysis of survival data may be violated. This study was conducted to investigate joint modeling of frequent events and a final event (death) in breast cancer patients using ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • British medical journal

دوره 2 6145  شماره 

صفحات  -

تاریخ انتشار 1978